Section I. Basic Mechanisms of Tolerance and Physical Dependence. - 1. Biological Models of Alcohol Tolerance and Physical Dependence. - 2. Neurochemical Aspects of Tolerance to and Dependence on Ethanol. - 3. A Role for Tetrahydroisoquinoline Alkaloids as False Adrenergic Neurotransmitters in Alcoholism. - 4. Addiction to Barbiturates and Ethanol: Possible Biochemical Mechanisms*. - Section II. Biochemical Aspects. - 1. Possible Role of Microsomal Changes Induced by Ethanol Intake in the Development of Tolerance and Dependence. - 2. Effects of Ethanol on Liver Metabolism*. - 3. Tryptophan Pyrrolase in Ethanol Administration and Withdrawal. - 4. The Metabolic Basis of Ethanol Toxicity. - 5. Biochemical Changes in Mitochondria as a Mechanism in Metabolic Tolerance to Ethanol. - 6. Hypothalamic-Pituitary-Adrenal Function in Chronic Alcoholics. - 7. Influence of Two Tetrahydrocannabinols (THC's) on the Activity of Biotransformation Enzymes. - Section III. Experimental Studies in Animals. - 1. Chronic Ingestion Techniques for the Production of Physical Dependence of Ethanol. - 2. Alcohol Oral Self-Administration in Rats: Attempts to Elicit Excessive Intake and Dependence. - 3. Evaluation of a Polydipsia Technique to Induce Alcohol Consumption in Monkeys*. - 4. Effects of Electrical Stimulation of the Lateral Hypothalamus on Ethanol Consumption. - Section IV. Experimental Studies of Sleep. - 1. Chronic Alcoholism Alcohol and Sleep. - 2. Correlation of Urinary Biogenic Amines with Sleep Stages in Chronic Alcoholization and Withdrawal. - 3. Sleep Changes Induced by 4 and 6 Days of Experimental Alcoholization and Withdrawal in Humans. - 4. Hallucinations During Experimental Intoxication*. - 5. Sensory Superactivity A Preliminary Report on an Hypothetical Model for an Hallucinogenic Mechanism inAlcohol Withdrawal*. - Section V. Human Experimental Studies (Excluding Sleep). - 1. Short-Term Memory Function in Alcohol Addicts During Intoxication*. - 2. The Effects of Alcohol on the Somatosensory Evoked Potentials in Man*. - 3. Affective Changes During 6 Days of Experimental Alcoholism and Subsequent Withdrawal. - 4. An Improved Quantitative System for Assessing the Acute Alcoholic Psychoses and Related States (TSA and SSA)*. - 5. Observations on the Prevalence of the Signs and Symptoms Associated with Withdrawal During Continuous Observation of Experimental Intoxication and Withdrawal in Humans. - 6. Recovery Function and Clinical Symptomatology in Acute Alcoholization and Withdrawal. Language: English