With Frontline Combo and its spot-on solution your dog will be protected against adult fleas, their eggs and larvae, lice and ticks. These pipettes are indicated for dogs between 2 and 10Kg. It acts in less than 24 hours with the highest effectiveness. Benefits - Frontline Combo is one of the few products marketed in Spain that has in its composition an adulticide molecule, for adult fleas, and a molecule that eliminates the immature forms (eggs and larvae), which makes it a very complete product to fight against these parasites. - It acts in 24 hours guaranteeing continuous protection. - It is patented and approved for veterinary use since it has been subjected to rigorous safety, efficacy and quality studies. In this way, it complies with the requirements and standards of each country. - These pipettes can be used in pregnant and lactating females. Indications - The application is recommended in pregnant females before the birth of the puppies, so the puppies will be protected from future inspections. - It can be applied in puppies more than 8 weeks old. - Do not shower the animal 48h before and after application. - It is resistant to baths, guaranteeing durability and protection. Instructions for use Remove the blisters from the cardboard box and separate a blister. Remove the pipette or spot on-cutting with scissors or bending the dotted line backwards. Separate the fur along the dorsal line of the dog or cat until the skin is visible. Place the tip of the pipette on the skin and start spreading the product well from the shoulder blade area to the middle of the back to prevent the animal from turning and licking. It is advisable not to put all the product in the same spot. The product will seep into the skin of our animal and will make a protective layer. Precautions - Do not use in dogs under 8 weeks old or from 1 to 2kg respectively. - If you detect any reaction in your dog go to your veterinarian and follow his instructions. TECHNICAL DATA SHEET Frontline Combo Spot-on Dog. Composition: Each ml contains: Fipronil 100.00 mg (S)-methoprene 90.00 mg. Target species: dogs. Indications: Flea infestations, alone or associated with ticks and/or biting lice. Contraindications: Do not use in puppies under 8 weeks of age. Do not use in sick (e.g. systemic disease, fever) or convalescent animals. Do not use in rabbits, since adverse reactions may occur, even resulting in death. Adverse reactions: Among the very rare adverse reactions the following have been reported: transient skin reactions at the site of application (skin discoloration, local hair loss, itching, redness) as well as general itching or hair loss. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed. Posology: Topical application on the skin. Minimum recommended dose of 6.7 mg/kg fipronil and 6 mg/kg (S)-methoprene. Minimum treatment interval is 4 weeks. Precautions: Avoid contact with the animal's eyes. Ensure that the drug is applied in an area where the animal cannot lick itself and that animals do not lick each other after treatment. Baths or immersion in water should be avoided during the 2 days following the application of the product as well as baths more frequent than once a week. Active ingredients: - Fipronil is the main active ingredient in the FRONTLINE product range. It is an insecticide/acaricide substance characterized by rapidity of action, an excellent safety profile and long lasting effects. - (S)-methoprene is an insect growth regulator (IGR) that has ovicidal and larvicidal activity preventing contamination of the environment of treated animals by immature flea stages.